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20)3)27(2)9-8-18(31)12-17(27)13-22(26)32
11 xenograft model
as well as autophagosome maturation
Trends Pharmacol Sci
TAK-683 TFA Catalog No.:M17751-C 20)3)27(2)9-8-18(31)12-17(27)13-22(26)32TAK 683 TFA is a potent full KISS1 receptor (KISS1R) agonist (IC50=170 pM) with improved metabolic stability. TAK 683 TFA is a nonapeptide metastin analog, exhibits agonistic activities to KISS1R with EC50 values of 0. 96 nM and 1. 6 nM for human and rat, respectively. TAK 683 TFA depletes GnRH in the hypothalamus and reduces plasma FSH, LH, and testosterone levels in vivo, it has the potential for the study of hormone dependent prostate cancer.
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